tRNA synthetase, WARS1

Tryptophanyl tRNA synthetase (WARS1) is an essential protein for cell survival as an enzyme link of tryptophan to the corresponding tRNA during protein synthesis.
It acts as the triggering factor for the induction of an inflammatory response by bindingto the Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4)-MD2 complexes on macrophages. Leading to the removal of invaded microorganisms by inducing the secretion of cytokines and chemokines.

WARS1 targeted
drug development strategy


Pipeline Indication Discovery PoC/MoA Lead Optimization CMC GLP TOX Clinical Phase I
MAb drug M101AI Disease 1
M102AI Disease 2
M103AI Disease 3
M104AI Disease 4
M105AI Disease 5
Protein drug M201AN Disease 6
M207AN Disease 7